This is a video that provides an overview of the basic concepts of Neoplasia. Neoplasia is a disease of genetic deregulation. Using a clinical case and the "Hallmarks of Cancer" concepts, this video covers the clinical-pathological-molecular correlation, and specific types of genetic defects seen in cancer. The latter portion of the video discusses the salient features associated with benign and malignant neoplasms, and respective nomenclature.